archenemy

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(n.) the foremost of one's enemies, opponents, or adversaries. an archenemy can define one's character as much as a friend or ally can, and in a sense, having one is therefore a necessary step to self-actualization.

famous archenemies include:
united states and soviet union
britain and france
sherlock holmes and professor moriarty
batman and joker
humanity and nature
louis pasteur and antoine béchamp
elvis and robert goulet

and so on
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